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Pharmaceutical & Biotech Industries

Today's pharmaceutical processes involve a large range of liquid blending operations. Methods range from simple liquid blending or heat transfer challenges, to gum and stabilizer dispersions, to complex emulsion creation.

We have solutions across all process levels within the pharmaceutical and biotechnology industries. Our mixing expertise combined with our understanding of common ingredients and APIs allows us to offer solutions that improve production with effective mixing, reduced horsepower and optimized capital costs.

Pharmaceutical Mixing Equipment

Our sanitary designs meet tough hygienic and safety standards for GMP facilities. They are constructed of FDA-approved materials and many are 3-A certified and comply with strict cGMP requirements. Factory Acceptance Testing (FAT), QA and full validation documentation packages are available.

Admix Free QuoteLet our application engineers recommend a customized pharmaceutical mixing solution for you or have your ingredient tested for free in our pilot lab.

Featured Video

See how the Rotosolver high shear mixer quickly and efficiently creates a smooth slurry from carboxymethyl cellulose (CMC), a popular thickening agent in pharmaceuticals.

Pharmaceutical Mixing Q&A

Looking for simple tank agitation, with volumes up to 60,000 gallons? The Rotomixx and RotoMAXX II lines offer fixed or portable tank agitation with all stainless steel construction. These solutions offer simple blending for miscible fluids, solids incorporation and dispersion, or can maintain a suspension. Both meet 3-A standard #73-01
Need consistent pill coating dispersions? Are you dispersing hard-to-wet powders that agglomerate or raft on top of the tank? The Rotosolver combines good product motion with efficient pumping blades and a high shear mixing region to break down fisheyes and agglomerates. It is CIP and meets 3-A standard #73-01.
Creating a cream or lotion that depends on a good, tight, stable emulsion? The Rotostat rotor-stator mixer provides bulk tank motion without any in-tank bearing frame or supporting arms to block product flow. Its high shear properties mechanically break down solids (like wax) used to give body to many creams, without requiring elevated temperature to melt these solids.
Developing new formulas or considering a different production method? The BenchMix programmable high shear lab mixer can be configured with Rotomixx, Rotosolver and Rotostat heads for flexibility and accurate scale-up to full production. Contact us to learn more about our scale-up methods and process performance guarantee.
Running product through multiple passes in a high pressure homogenizer, filtering out lumps and fisheyes or trying to finish refine a product before the filler machines? For in-line continuous processing, the DynaShear and Boston Shearmill high shear mixers and wet mills provide tight emulsions. Typical droplet size for DynaShear is 2-3 microns and as fine as 0.5 microns with the Boston Shearmill. Both break down tough fisheyes in a single pass and deagglomerate a fluid stream to save filter cleaning and wasted raw material. Both are designed to run 24/7 and meet 3-A standard #36-01.
Looking for improved, safer methods of incorporating powders? The VacuShear system inducts powders or liquids under vacuum, providing high shear mixing for immediate powder dispersion, and vacuum deaeration for the best finished product. Where air entrainment is not a concern, our powder induction line-up of Optifeed, PIC and Fastfeed provide inline, continuous powder dispersion at controlled feed rates up to 450 lbs/minute.

 

Pharmaceutical Brochure Low Shear Rotomixx & Rotomaxx High Shear Rotosolver & Rotostat
Pharmaceutical
Market Brochure
Low Shear
Rotomixx & Rotomaxx
High Shear
Rotosolver & Rotostat